Philippe Moreau, MD, Nantes University Hospital, Nantes, France, discusses the use of measurable residual disease (MRD) negativity as a surrogate for progression-free survival (PFS) and overall survival (OS) in both the frontline and relapsed/refractory setting. Prof. Moreau explores the key questions regarding the use of MRD, such as what the optimal techniques are to obtain the measure, such as through flow cytometry or next-generation sequencing (NGS), as well as what the optimal MRD threshold is. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.