Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, discusses the developments in hematological malignancies seen at ASH 2020. With the use of single-cell mutational analysis and epigenomics tools, there is an increasing understanding of the mechanisms of disease progression and evolution. As well as this, clinical advancements have been made in every major disease area, with growing use of novel agents and new drug combinations. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.