In this video, Claire Harrison, MD, DM, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, discusses the promise of combining navitoclax with ruxolitinib for the treatment of myelofibrosis (MF), and important factors to consider when selecting patients for this combination. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.