ASH 2025 | Update on NUTRIVENTION-2 and NUTRIVENTION-3: high-fiber dietary intervention for MGUS and SMM
Urvi Shah, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, discusses the ongoing NUTRIVENTION-2 (NCT06055894) and NUTRIVENTION-3 (NCT05640843) trials investigating the impact of a high-fiber dietary intervention on biomarkers of disease in participants with monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM). If you’re interested in getting in touch, please contact: shahnutrivention@mskcc.org. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.
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Transcript
We conducted the pilot NUTRIVENTION study in participants with an elevated body mass index with MGUS and smoldering myeloma to see how a dietary intervention that is high in fiber could potentially improve biomarkers of disease and delay progression. The pilot NUTRIVENTION study was published in Cancer Discovery recently and we now have two follow-up studies, the NUTRIVENTION-2 and NUTRIVENTION-3 studies that are currently enrolling...
We conducted the pilot NUTRIVENTION study in participants with an elevated body mass index with MGUS and smoldering myeloma to see how a dietary intervention that is high in fiber could potentially improve biomarkers of disease and delay progression. The pilot NUTRIVENTION study was published in Cancer Discovery recently and we now have two follow-up studies, the NUTRIVENTION-2 and NUTRIVENTION-3 studies that are currently enrolling. NUTRIVENTION-2 is a study in patients with MGUS and smoldering myeloma. It is in collaboration with the Health Tree Foundation. It is a completely decentralized study, meaning that a participant does not need to travel to do the study and they can be living anywhere across the United States. The study will be open till early next year. So if you are interested, please reach out and we would love to have your participation if you have MGUS or smoldering myeloma. The enrollment criteria are very broad. And so, again, email shahnutrivention@mskcc.org if you’re interested. We also have another study, the NUTRIVENTION-3 trial. This study is looking at a high-fiber diet versus supplements such as curcumin and algae-based omega-3. And all participants in the study will receive the diet. It’s just whether they get it in the beginning or later in the study. This study requires a participant to travel to either Emory or Memorial Sloan-Kettering for about four to six visits spread over a year. If you are interested in this study, it is fine to be living anywhere across the country as long as you’re willing to travel for about four to six visits. And this study is more involved where we provide the food for three months, whereas NUTRIVENTION-2 is a short two-week study where we are looking at microbiome changes alone with three different supplements, the curcumin, omega-3, and probiotics versus diet.
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