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BSH 2022 | Recent updates from ECHELON-1 and implications for the treatment of HL

Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, gives an overview of recent updates in the treatment of Hodgkin lymphoma (HL), drawing focus on the recent ECHELON-1 (NCT01712490) trial investigating the use of brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine (A+AVD) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) in patients with HL. Dr Collins briefly discusses some of the results obtained in this trial, including the recent overall survival (OS) benefit which has been reported. Although data still needs to be presented on the relevance of this OS benefit, Dr Collins discusses the exciting implications that these findings may have for older patients who are unable to withstand the intensity of the commonly used escalated BEACOPP approach. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.


Honoraria: Roche, Takeda, Gilead, Pfizer, MSD, Celleron, ADC Therapeutics, Incyte, Beigene. Research funding: BMS, MSD, Celleron, Amgen, BMS

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