Mikkael Sekeres, MD, MS, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, discusses the methods and features behind the National MDS Natural History Study (NCT02775383), which assembles a comprehensive biorepository of both clinical and laboratory data. This interview took place at the 2nd Regional Symposium on Myelodysplastic Syndromes (MDS 2020), held in Tel Aviv, Israel.