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iwHRMM 2024 | Managing patients with myeloma who are penta-refractory and have exhausted BCMA-targeting therapies

Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, briefly discusses the limited treatment options for patients with multiple myeloma (MM) who are penta-refractory and have failed prior anti-BCMA therapy, noting the promise of targeting GPRC5D as a new therapeutic approach. She highlights alternative agents, such as melflufen and selinexor, but acknowledges that clinical outcomes in this patient population remain suboptimal. This discussion took place at the 1st International Workshop on High-Risk Multiple Myeloma (iwHRMM 2024), held in Charleston, SC.

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