Abdulraheem Yacoub, MD, of the University of Kansas Medical Center, Kansas City, MO, outlines novel therapy approaches and pitfalls in the treatment of myeloproliferative neoplasms (MPNs). Dr Yacoub explores the use of JAK inhibitors for this indication as well as ongoing clinical trials investigating combination therapies for MPNs. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).