ISAL 2023 | The impact of various chromosomal abnormalities observed in AML & insights into RUNX1-ETO
Constanze Bonifer
• 16 Mar 2023
In this video, Constanze Bonifer, PhD, University of Birmingham, Birmingham, UK, shares some insights into chromosomal abnormalities seen in acute myeloid leukemia (AML) and how these impact gene regulation. Prof. Bonifer explains that the t(8;21) translocation gives rise to the fusion oncoprotein RUNX1-ETO, and then goes on to highlight how RUNX1-ETO may activate or repress genes during blood cell development. This interview took place at the 18th International Symposium on Acute Leukemias (ISAL XVIII), held in Munich, Germany.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
