ISAL 2023 | Using transcriptional network analysis to better understand AML development and evolution
Constanze Bonifer, PhD, University of Birmingham, Birmingham, UK, discusses ongoing research into gene regulatory networks in acute myeloid leukemia (AML). Prof. Bonifer explains that each mutational subtype of AML is maintained by its own gene regulatory network, and then goes on to summarize some important findings. This research has demonstrated that there is a regulatory circuit consisting of oncoproteins, signaling pathways and transcription factors, which all play a role in mediating the growth of leukemic blast cells. This interview took place at the 18th International Symposium on Acute Leukemias (ISAL XVIII), held in Munich, Germany.
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