Francois-Xavier Mahon, MD, PhD, University of Bordeaux, Bordeaux, France, highlights unanswered questions regarding treatment discontinuation for patients with chronic myeloid leukemia (CML). Prof. Mahon notes that the mechanisms underlying late molecular recurrence are unclear and likely differ from those responsible for early recurrence in CML. Further research is needed to understand these processes and enable more accurate decision making regarding the feasibility of stopping treatment in an individual patient. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.