In this video, Mattia D’Agostino, MD, University of Turin, European Myeloma Network, Turin, Italy, shares some insights into the importance of measurable residual disease (MRD) as a prognostic tool in multiple myeloma. Dr D’Agostino then highlights predictors of unsustained MRD negativity observed in patients enrolled in the FORTE trial (NCT02203643), including circulating tumor cells (CTCs) and chromosome 1q abnormalities. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.