In this discussion, Heinz Ludwig, MD, Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, and Meral Beksac, MD, Ankara University, Ankara, Turkey, explore the different parameters that can be used to define high-risk multiple myeloma, including genetic, clinical, and biological features, and discuss optimal treatment strategies for this patient population, commenting on the possibility of incorporating bispecific antibodies and CAR-T therapy in the treatment regimen of patients with high-risk disease, and briefly discussing the prognostic value of sustained measurable residual disease (MRD) negativity in these patients. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.
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