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COMy 2025 | Common clinical presentations or symptoms of extramedullary myeloma
Meral Beksac, MD, Istinye University Ankara Liv Hospital, Ankara, Turkey, outlines the common clinical presentations and symptoms of extramedullary multiple myeloma (MM). Dr Beksac highlights that the symptoms are defined by the localization of the extramedullary disease, leading to a diverse range of manifestations and a unique symptomatology. This interview took place at the 11th World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France.
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Transcript
So the presentation of the extramedullary disease may differ. The paraosseous spread from the bone, this really doesn’t make a major impact on the course of the disease. This is called the paraskeletal or paraparaosseous form. The real extramedullary disease are the ones which are not in the proximity of the bone or bone marrow, but they occur such as in the skin, in organs such as the liver, in lymph nodes, in, for instance, the lungs or even in the central nervous system...
So the presentation of the extramedullary disease may differ. The paraosseous spread from the bone, this really doesn’t make a major impact on the course of the disease. This is called the paraskeletal or paraparaosseous form. The real extramedullary disease are the ones which are not in the proximity of the bone or bone marrow, but they occur such as in the skin, in organs such as the liver, in lymph nodes, in, for instance, the lungs or even in the central nervous system. So the symptoms, the presentations are defined by the localization. In the skin you can notice a very bizarre type of infiltrations, which can grow up and in lymph nodes may enlarge and the intra-abdominal lesions may have a compression on for instance the urinary tract and also on the lymphatic system which causes a swelling on the legs. So there is a very bizarre presentation with different symptomatology.
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