IMS 2023 | ANCHOR and LIGHTHOUSE trials: melflufen in multiple myeloma
Paul Richardson, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the approval status, mechanism of action, and efficacy of melflufen in multiple myeloma. Melflufen is a peptide-drug conjugate which targets aminopeptidases and releases alkylating agents directly into tumor cells. Dr Richardson discusses the results of the Phase I/IIa ANCHOR trial (NCT03481556) which showed that melflufen and dexamethasone in combination with either bortezomib or daratumumab produced very encouraging response rates. The Phase III LIGHTHOUSE study (NCT03481556), although terminated early, indicated that melflufen combined with daratumumab and dexamethasone provided a therapeutic benefit compared to daratumumab and dexamethasone alone. This interview took place at the 20th International Myeloma Society (IMS) Annual Meeting, held in Athens, Greece.
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Disclosures
Consulting: Oncopeptides, Celgene/BMS, Karyopharm, Sanofi, GSK
Research grant: Oncopeptides, Celgene/BMS, Karopharm, Takeda
