Claire Harrison, MD, DM, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, comments on the use of different JAK inhibitors including ruxolitinib, pacritinib, fedratinib, or momelotinib for treatment of patients with myelofibrosis (MF) who are thrombocytopenic, highlighting the results of recent retrospective analyses comparing pacritinib with ruxolitinib, and fedratinib with ruxolitinib in this setting. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.