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The 2022 Tandem Meetings | Lentiviral vectors for HSC gene therapy

Luigi Naldini, MD, PhD, San Raffaele Telethon Institute for Gene Therapy, Milano, Italy, talks on the use of lentiviral vectors for hematopoietic stem cell (HSC) gene therapy, highlighting the benefits of autologous HSCs. Lentiviral vectors are used to treat a wide range of genetic diseases including primary immunodeficiencies, hemoglobinopathies, and metabolic storage disorders. Gene therapy using autologous HSCs enables patients to be treated with a milder conditioning regimen, with no risk of rejection or graft-versus-host disease (GvHD). This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.