Luigi Naldini, MD, PhD, San Raffaele Telethon Institute for Gene Therapy, Milano, Italy, gives an overview of current and emerging genetic engineering platforms for hematopoietic stem cells (HSCs). Lentiviral vector-mediated gene transfer is currently the most advanced platform for HSC gene therapy. Other promising tools including CRISPR-Cas9 gene editing have entered early clinical testing. This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.