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The 2022 Tandem Meetings | Advances in tools for genetic engineering of HSCs

Luigi Naldini, MD, PhD, San Raffaele Telethon Institute for Gene Therapy, Milano, Italy, gives an overview of current and emerging genetic engineering platforms for hematopoietic stem cells (HSCs). Lentiviral vector-mediated gene transfer is currently the most advanced platform for HSC gene therapy. Other promising tools including CRISPR-Cas9 gene editing have entered early clinical testing. This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.