Valeria Santini, MD, University of Florence, Florence, Italy, discusses the future of treatment for patients with myelodysplastic syndromes (MDS), emphasizing that the main paradigm shift will be towards a more personalized system. The findings of several ongoing, large scale clinical trials investigating the combination of hypomethylating agents with novel therapies will likely have a significant impact on the standard of care in MDS. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.