Lenalidomide is an immunomodulatory drug (IMiD) used for the treatment of myeloma and is known to provide significant clinical benefits to patients. In this video, Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, briefly discusses lenalidomide’s place in the myeloma treatment armamentarium, highlighting its use in triplet and quadruplet combinations. Dr Neri also discusses the benefit of using lenalidomide for maintenance therapy, and the potential benefit of using other CELMoDs and IMiDs for the treatment of myeloma. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.