SITC 2021 | Modulating the epigenome of exhausted T-cells
Debattama Sen
• 13 Nov 2021
Debattama Sen, PhD, Massachusetts General Hospital, Boston, MA, describes the epigenomic features of exhausted T-cells during immunotherapy and outlines how they may be targeted. Exhausted T-cells in the tumor microenvironment are highly variable and epigenetically distinct from functional T-cells, and it is difficult to revert dysfunctional T-cells back to functional T-cells using immunotherapeutic agents. A recent study has shown that it is possible to target T-cell exhaustion without affecting functional cells by editing the enhancers regulating gene expression in exhausted T-cells. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.
