In this video, Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany, discusses the current standard of care (SOC) in blastic plasmacytoid dendritic cell neoplasm (BPDCN), drawing focus on the use of tagraxofusp, as well as the use of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)-based regimens and the importance of transplantation. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.