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ASH 2022 | MASTER subgroup analysis: quadruplet induction, autoSCT & treatment cessation in NDMM patients ≥70

Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, discusses the results from a subgroup analysis of the Phase II MASTER trial (NCT03224507), which analyzed quadruplet induction, autologous stem cell transplantation (autoSCT) and measurable residual disease (MRD)-guided treatment cessation in patients with newly diagnosed multiple myeloma (NDMM) aged 70 or older. Results demonstrated that while there was a slight difference in the frequency of achieving MRD negativity, there was no difference in safety observed between younger and older patients. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Disclosures

Sanofi: Consultancy, Honoraria; Adaptive Biotechnologies: Consultancy, Honoraria; Bristol Myers Squibb: Consultancy, Honoraria, Research Funding; Genentech: Research Funding; AbbVie: Research Funding; Amgen: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria, Research Funding.