ASH 2019 | JAKARTA2 update: fedratinib in MF patients previously treated with ruxolitinib

Ruben Mesa

Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, discusses the efficacy and safety results of fedratinib, a selective JAK2 inhibitor, in JAKARTA2 trial (NCT01523171) patients who were resistant or intolerant to ruxolitinib. Fedratinib showed great activity, and reduced spleen volume and symptom burden in patients with myeloproliferative neoplasm-associated myelofibrosis (MF). Dr Mesa highlights how these findings help to validate the use of fedratinib in the second-line setting. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.

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