ASH 2023 | A Phase I trial of voruciclib +/- venetoclax for the treatment of NHL and AML
Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, introduces a Phase I trial (NCT03547115) assessing voruciclib, a potent CDK9 inhibitor (CDK9i), alone or combined with venetoclax in patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL) or acute myeloid leukemia (AML). Findings from the ongoing trial demonstrate encouraging preliminary efficacy and safety, with no significant myelosuppression being observed. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: MEI, Lilly Oncology, Nurix, Abbvie, Beigene, Janssen, Astra Zeneca, Bristol Meyers Squibb, Genentech, GenMab, Merck
Research Funding: MEI, Lilly Oncology, Cyclacel, Bayer, Nurix, Abbvie, Beigene, Astra Zeneca, Bristol Meyers Squibb, GenMab
