Michel Delforge, MD, PhD, University of Leuven, Leuven, Belgium, discusses possible strategies to optimize CAR-T therapy in patients with multiple myeloma. Despite the promise of these agents, many patients relapse after treatment with CAR-T cells, emphasizing the need to improve outcomes. Prof. Delforge comments on the possibility of bringing CAR-T cells into earlier lines and highlights trials exploring this, including KarMMa-3 (NCT03651128) and CARTITUDE-4 (NCT04181827). This interview took place at the 9th World Congress on Controversies in Multiple Myeloma (COMy) 2023, held in Paris, France.
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