Melissa Bou Jaoudeh, PhD, Sorbonne University, Paris, France, highlights some of the challenges in the management of patients with hemophilia with inhibitors, discussing the influence of bypassing agents on artieral and venous thrombotic events, and emphasizing the importance of eradicating inhibitors in this patient population. This interview took place at the 30th Congress of the International Society on Thrombosis and Haemostasis (ISTH) 2022 held in London, UK