Melissa Bou Jaoudeh, PhD, Sorbonne University, Paris, France, comments on the therapeutic potential of IdeS for the treatment of patients with hemophilia A with inhibitors, highlighting the results of an in vivo experiment using a humanized mouse model. The study showed that IdeS led to anti-factor VIII antibody elimination as well as recovery of factor VIII activity. In addition, subsequent injection of factor VIII led to a decrease in blood loss in a tail-clip bleeding model. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.