Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on survival outcomes in patients with myelofibrosis (MF) and how novel agents, such as JAK inhibitors, have improved patient quality of life and symptoms. Dr Masarova also explains the challenges with directly assessing survival outcomes and the need to obtain more detailed data from clinical trials. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.