Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, shares some insights into the treatment and management of blast-phase myeloproliferative neoplasms (MPN-BP), which represent a major unmet need in the field. Dr Masarova highlights the poor prognosis associated with patients who present with MPN-BP, and further emphasizes the need to design better clinical trials and investigate more therapeutic options for these patients. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.