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ASH 2022 | Primary analysis of the TRANSFORM study: liso-cel vs SOC as second-line treatment for R/R LBCL

Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, shares the results from the primary analysis of the Phase III TRANSFORM study (NCT03575351) comparing lisocabtagene maraleucel (liso-cel) versus standard of care (SOC) with salvage chemotherapy followed by autologous stem cell transplantation (autoSCT) as second-line treatment in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). After a median follow-up of 17.5 months, the event-free survival (EFS) was not reached in the liso-cel arm and was 2.4 months in the SOC arm. In addition, there were no serious adverse events and no new safety signals. Patients who crossed over to receive liso-cel after they did not achieve complete or partial response with SOC had a worse EFS than patients who were treated directly with liso-cel. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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TG Therapeutics: Consultancy, Research Funding; Genentech: Consultancy, Other: DMC, Research Funding; Novartis: Research Funding; Abbvie: Consultancy; AstraZeneca: Consultancy; BMS: Consultancy; Adaptive Technologies: Consultancy; ADC Therapeutics: Consultancy; Beigene: Consultancy; Impact Bio: Consultancy; SeaGen: Speakers Bureau; Celgene: Other: DMC.

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