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ASH 2023 | An overview of the toxicities associated with immunotherapy in multiple myeloma
Surbhi Sidana, MD, Stanford University, Stanford, CA, gives an overview of the toxicities that are associated with immunotherapy with bispecific antibodies and CAR-Ts in the treatment of multiple myeloma (MM). There are currently five FDA-approved immunotherapies, with the most common short-term adverse events (AEs) being cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), hemophagocytic lymphohistiocytosis (HLH)–like toxicities, cytopenias, and infections. Dr Sidana emphasizes the importance of managing CRS in both bispecific and CAR-T treatment rapidly with the use of tocilizumab. Although rare, secondary primary malignancies following CAR-T treatment are being investigated by the FDA. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Magenta Therapeutics, BMS, Janssen, Sanofi, Oncopeptides, Takeda, Pfizer
Research Funding: Magenta Therapeutics, BMS, Allogene, Janssen, Novartis
