EHA 2024 | Revumenib plus azacitidine and venetoclax in older adults with NPM1-mutated or KMT2A-rearranged AML
Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, discusses the safety and efficacy of azacitidine, venetoclax, and revumenib in newly diagnosed older adults with NPM1-mutated or KMT2A-rearranged acute myeloid leukemia (AML) in the Beat AML Master trial (NCT03013998). The study investigated two dose levels of revumenib, finding no non-hematologic dose-limiting toxicities (DLTs) and one hematologic DLT at the first dose level. Among all evaluable patients, there was a 100% overall response rate (ORR) and a 96% composite complete remission (CRc) rate. A Phase III trial for this combination is now being planned. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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Disclosures
Consulting fees and/or honoraria: AbbVie, Daiichi Sankyo, Foghorn, Gilead, Novartis, Sellas, Servier, Shattuck Labs, Sumitomo Dainippon, Syndax; Research funding: AbbVie, Arog, Jazz, Gilead, Loxo, Merck, Newave, Novartis, Sellas, Shattuck Labs, Stemline, Sumitomo Dainippon, Takeda, Zentalis.
