Abdulraheem Yacoub, MD, University of Kansas Medical Center, Kansas City, MO, updates us on the clinical use of momelotinib, a JAK1/JAK2 inhibitor in patients with myelofibrosis, including the results of the SIMPLIFY-1 study (NCT01969838), evaluating momelotinib against ruxolitinib in patients with myelofibrosis. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).