Florence Cymbalista, MD, of Hôpital Avicenne, Bobigny, France, explores clinical trials evaluating the use of second generation BTK inhibitors such as zanubrutinib and acalabrutinib for chronic lymphocytic leukemia (CLL), and their potential benefits over ibrutinib. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).