ASCO 2018 | CAR T-cell update: what’s new in DLBCL and MM?

David Maloney

CAR T-cells represent an exciting new treatment frontier across a variety of blood cancers. We interviewed David Maloney, MD, PhD, of the Fred Hutchinson Cancer Research Center, Seattle, WA, at the American Society of Oncology (ASCO) 2018 Annual Meeting in Chicago, IL, about the newest CAR T-cell therapies on the market. In diffuse large B-cell lymphoma (DLBCL), he highlights axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel, the latter of which has extremely promising safety results, with low levels of cytokine release syndrome and neurotoxicity. Dr Maloney also discusses new multiple myeloma (MM) CAR T-cell treatments, pointing out a trial (NCT02658929) showing deep responses and remission in relapsed patients with multiple prior therapies when treated with the CAR T-cell agent bb2121.

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