Steven Rosen, MD of City of Hope, Duarte, CA discusses projects currently underway at the City of Hope. Prof. Rosen explains that they are developing their own CAR T-cells with a focus on blood cancers, but also some targeting solid tumors. Further, there are vaccine trials for solid tumors, blood cancers and infections. There is a group that have produced stem cells that home in on cancer when injected intravenously, and they are used as carriers for delivering chemotherapeutics or oncolytic viruses. Prof. Rosen himself is working on two projects: a novel nucleoside analogue that is RNA-directed rather than DNA-directed and further, the re-purposing of a drug for arthritis (flutamide) for multiple myeloma (MM). Recorded at the 2016 International Workshop on Non-Hodgkin Lymphoma (iwNHL) meeting held in San Diego, CA.