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ASH 2019 | Integrated sequencing in AML/MDS reveals prognostic constellations

Genomic sequencing studies are needed to gain a better understanding of the pathogenesis of myeloid malignancies. Here, Ilaria Iacobucci, PhD, St. Jude Children’s Research Hospital, Memphis, TN, discusses the integrated genome-wide mutational/transcriptomic analysis performed on a large cohort of adult acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) samples to accurately define subtypes of diagnostic, prognostic and therapeutic relevance. Genomic/transcriptome sequencing and gene expression analysis enabled the definition of subtypes and constellations of mutations in AML and MDS, which have prognostic significance that surpasses previous gene panel-based classifications. This press briefing was recorded at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.

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