EHA 2026 | Updated genomic insights in Ph+ acute lymphoblastic leukemia.
Ilaria Iacobucci, PhD, St. Jude Children’s Research Hospital, Memphis, TN, shares updated insights into the genomics of Ph-positive acute lymphoblastic leukemia (Ph+ ALL), highlighting that, beyond BCR-ABL, cooperating genetic alterations, such as IKZF1 deletions, influence treatment response and relapse risk. Dr Iacobucci also discusses how cell developmental state shapes disease biology, with single-cell sequencing identifying two subgroups: an immature, early progenitor-like subtype and a more differentiated pro-B-cell-like subtype. This interview took place at the 31st Congress of the European Hematology Association (EHA) in Stockholm, Sweden.
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