Autologous stem cell transplant (ASCT) has been utilized in the management of immunoglobulin light chain (AL) amyloidosis for several decades. The use of ASCT has been associated with high rates of hematologic response and improvement in organ function. However, novel agents have challenged the use of ASCT. Eli Muchtar, MD, Mayo Clinic, Rochester, MN, discusses the burning questions in the use of ASCT in AL amyloidosis. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).