Speaking from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA, Jennifer Woyach, MD, of the Ohio State University College of Medicine, Columbus, OH, discusses the results of the COSMOS trial (NCT02639910), investigating anti-CD19 MOR208 in combination with venetoclax in chronic lymphocytic leukemia (CLL) patients who discontinued BTK inhibitor therapy. This revealed encouraging activity, with acceptable safety and tolerability.