iwMyeloma 2022 | Novel promising agents and clinical trials in amyloidosis
In this video, Angela Dispenzieri, MD, Mayo Clinic, Rochester, MN, discusses ongoing clinical trials in amyloidosis, sharing some insights into novel agents and the future treatment landscape of amyloidosis. First, Dr Dispenzieri discusses two trials that are investigating the use of CAEL-101, an antibody designed to remove AL amyloid deposits from tissues and organs, in patients with stage IIIa and IIIb disease. Dr Dispenzieri then discusses a trial investigating the use of NEOD001 to treat patients with stage IV disease, and the hope that novel immunotherapies used in the myeloma setting will eventually be used for the treatment of amyloidosis. To conclude, Dr Dispenzieri discusses the importance of monitoring cardiac biomarkers and considering toxicity when treating patients with amyloidosis, and the possibility of using venetoclax-based treatment approaches in amyloidosis. This interview took place at The International Workshop on Myeloma 2022, held in Scottsdale, AZ.
