Prithviraj Bose, MBBS, MD Anderson Cancer Center, Houston, TX, explores the next generation JAK inhibitors, momelotinib and pacritinib, which have been receiving increasing attention for the treatment of myelofibrosis in the past decade. Dr Bose discusses the niche patient sub-group characterized by a cytopenic phenotype and those with anemia which may benefit from such agents, highlighting the MOMENTUM trial (NCT04173494) which is comparing momelotinib to danazol for patients previously treated with a JAK inhibitor. This interview took place at the Texas MPN Workshop: Second Annual Workshop and Meeting in 2021.