Josep-Maria Ribera, MD, PhD, Germans Trias i Pujol University Hospital, Barcelona, Spain, shares his highlights from ASH 2020 in the field of acute lymphoblastic leukemia (ALL). In particular, he discusses trials of novel agents in the frontline setting, including blinatumomab, inotuzumab, venetoclax, navitoclax and bortezomib. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.