Despite the very promising response rates seen with CAR T-cells in multiple myeloma (MM), the accompanying toxcities must also be considered. Speaking at the European School of Haematology (ESH) International Conference on Multiple Myeloma 2018, held in Mandelieu, France, Jesús Berdeja, MD, of the Sarah Cannon Center for Blood Cancer, Nashville, TN, discusses the toxicity profile of these agents in MM, namely cytokine release syndrome and neurotoxicity. Dr Berdeja highlights the frequency of such occurences, and the measures that can be taken to prevent and treat them.