ASCO 2023 | Real-world outcomes of brexu-cel in patients with R/R MCL
Swetha Kambhampati, MD, City of Hope, Duarte, CA, provides an update on an analysis of the real-world outcomes of brexucabtagene autoleucel (brexu-cel) in patients with relapsed/refractory mantle cell lymphoma (R/R MCL). The study analyzed high-risk, pretreated patients, including patients who had received prior BTK inhibitors, bendamustine, and stem cell transplantation (SCT). Real-world outcomes were comparable to the findings of ZUMA-2 (NCT02601313). Prior exposure to BTK inhibitors and bendamustine did not affect brexu-cel efficacy and safety, while prior autoHCT improved progression-free survival (PFS). Dr Kambhampati compares brexu-cel outcomes based on the number of prior lines of therapy and highlights the need for a longer follow-up. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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