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IMS 2022 | GEMKyCyDex: KCyd vs Kd in patients with R/R multiple myeloma

Borja Puertas-Martinez, MD, University Hospital of Salamanca, Salamanca, Spain, gives an overview of the results of GEMKyCyDex, a Phase II study comparing carfilzomib, dexamethasone, and cyclophosphamide (KCyd) with carfilzomib plus dexamethasone (Kd) in patients with relapsed/refractory (R/R) multiple myeloma. Overall, the study did not observe a significant difference between both arms. However, lenalidomide-refractory patients in the KCyd arm had an improved progression-free survival (PFS). The study also reported an increased rate of toxicity in the KCyd arm. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.

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