Farhad Ravandi, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses the combination of hypomethylating agents (HMA) with venetoclax in elderly and unfit patients with acute myeloid leukemia (AML), commenting on the benefits of an all-oral treatment regimen in this patient population. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.