Raajit Rampal, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, summarizes some interesting highlights from the myeloproliferative neoplasm (MPN) sessions at ASH 2021. Dr Rampal draws focus on the number of therapeutic agents that are progressing in the treatment landscape of rare diseases including myelofibrosis, essential thrombocythemia, polycythemia vera, mastocytosis, and FGFR1-rearranged myeloid lymphoid disease. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.