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ASH 2025 | Enhanced T-cell fitness in high-risk smoldering vs R/R myeloma with bispecifics and CAR-T

Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, discusses single-cell immune profiling showing superior immune fitness of both endogenous and engineered T-cells in patients with high-risk smoldering myeloma compared with those treated in the relapsed/refractory (R/R) setting. She explains the potential benefit of earlier use of bispecific antibodies and CAR T-cell therapies by leveraging a more intact immune system. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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